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mFISH - WHOLE CHROMOSOME PAINTS

Tumor cytogenetics

mFISH with whole chromosome paints as probes is extensively applied in tumor cytogenetics.
For review see:

  • Bayani JM, Squire JA (2002) Applications of SKY in cancer cytogenetics. Cancer Invest 20:373-386. Review.
  • Calasanz MJ, Cigudosa JC (2008) Molecular cytogenetics in translational oncology: when chromosomes meet genomics. Clin Transl Oncol 10:20-29
  • Nowell PC, Rowley JD, Knudson AG Jr (1998) Cancer genetics, cytogenetics--defining the enemy within. Nat Med 4: 1107-1111.

Leukemia

  • Abe S, Ishikawa I, Harigae H, Sugawara T (2008) A new complex translocation t(5;17;15)(q11;q21;q22) in acute promyelocytic leukemia. Cancer Genet Cytogenet 184:44-47.
  • Abdelhaleem M, Shago M, Sayeh E, Abla O (2007) Childhood myeloid/natural killer precursor acute leukemia with novel chromosomal aberrations der(5)t(4;5)(q31;q31.3) and t(14;17)(q32;q23). Cancer Genet Cytogenet 178:141-143.
  • Ahuja HG, Popplewell L, Tcheurekdjian L, Slovak ML (2001) NUP98 gene rearrangements and the clonal evolution of chronic myelogenous leukemia. Genes Chr Cancer 30: 410-415.
  • Al Achkar W, Wafa A, Mkrtchyan H, Moassas F, Liehr T (2010) A rare case of chronic myeloid leukemia with secondary chromosomal changes including partial trisomy 17q21 to 17qter and partial monosomy of 16p13.3. Mol Cytogenet 3:6.
  • Al Achkar W, Wafa A, Ali BY, Manvelyan M, Liehr T (2010) A rare chronic myeloid leukemia case with Philadelphia chromosome, BCR-ABL e13a3 transcript and complex translocation involving four different chromosomes. Oncol Lett 1:797-800.
  • Al Achkar W, Wafa A, Mkrtchyan H, Moassass F, Liehr T (2010) A rare case of Philadelphia chromosome-positive chronic myelogenous leukemia with inversion in chromosome 9 and t(10;17). Oncol Lett 1:793-795.
  • Andersen MK, Christiansen DH, Pedersen-Bjergaard J (2005) Centromeric breakage and highly rearranged chromosome derivatives associated with mutations of TP53 are common in therapy-related MDS and AML after therapy with alkylating agents: An M-FISH study. Genes Chr Cancer 42: 358-371.
  • Avet-Loiseau H, Daviet A, Brigaudeau C, Callet-Bauchu E, Terre C, Lafage-Pochitaloff M, Desangles F, Ramond S, Talmant P, Bataille R (2001) Cytogenetic, interphase, and multicolor fluorescence in situ hybridization analyses in primary plasma cell leukemia: a study of 40 patients at diagnosis, on behalf of the Intergroupe Francophone du Myelome and the Groupe Francais de Cytogenetique Hematologique. Blood 97: 822-825.
  • Babicka L, Zemanova Z, Pavlistova L, Brezinova J, Ransdorfova S, Houskova L, Moravcova J, Klamova H, Michalova K (2006) Complex chromosomal rearrangements in patients with chronic myeloid leukemia. Cancer Genet Cytogenet 168:22-29.
  • Bacher U, Haferlach T, Schoch C (2005) Gain of 9p due to an unbalanced rearrangement der(9;18): a recurrent clonal abnormality in chronic myeloproliferative disorders. Cancer Genet Cytogenet 160: 179-183
  • Bacher U, Haferlach T, Kern W, Harich HD, Schnittger S, Haferlach C (2007) A case of chronic myeloproliferative syndrome followed by precursor T-cell acute lymphoblastic leukemia. Cancer Genet Cytogenet 175:52-56.
  • Bacher U, Haferlach C (2008) FISH in the diagnosis of hematological neoplasias. Medgen 20: 367-373. (German)
  • Bai S, Xue Y, Wu Y, Pan J, Zhang J, Shen J, Wang Y, Qiu H (2008) [Simultaneous presence of ins (15;17),t(2;17;20) and trisomy 8 in a patient with acute promyelocytic leukemia.] Zhonghua Yi Xue Yi Chuan Xue Za Zhi 25:712-714. Chinese.
  • Bakshi SR, Patel BP, Brahmbhatt MM, Trivedi PJ, Gajjar SB, Iyer RR, Parikh EH, Shukla SN, Shah PM (2009) Complex karyotype with a masked Philadelphia translocation and variant BCR-ABL fusion in CML. Cancer Genet Cytogenet 189:142-143.
  • Barber KE, Ford AM, Harris RL, Harrison CJ, Moorman AV (2004) MLL translocations with concurrent 3' deletions: interpretation of FISH results. Genes Chromosomes Cancer 41:266-271.
  • Barbouti A, Johansson B, Hoglund M, Mauritzson N, Strombeck B, Nilsson PG, Tanke HJ, Hagemeijer A, Mitelman F, Fioretos T (2002) Multicolor COBRA-FISH analysis of chronic myeloid leukemia reveals novel cryptic balanced translocations during disease progression. Genes Chromosomes Cancer 35: 127-137.
  • Barouk-Simonet E, Soenen-Cornu V, Roumier C, Cosson A, Lai JL, Fenaux P, Preudhomme C (2005) Role of multiplex FISH in identifying chromosome involvement in myelodysplastic syndromes and acute myeloid leukemias with complex karyotypes: a report on 28 cases. Cancer Genet Cytogenet 157:118-126.
  • Batista DA, Vonderheid EC, Hawkins A, Morsberger L, Long P, Murphy KM, Griffin CA (2006) Multicolor fluorescence in situ hybridization (SKY) in mycosis fungoides and Sezary syndrome: search for recurrent chromosome abnormalities. Genes Chromosomes Cancer 45: 383-391.
  • Betts DR, Niggli FK, Cohen N, Rechavi G, Amariglio N, Trakhtenbrot L (2008) SKY reveals a high frequency of unbalanced translocations involving chromosome 6 in t(12;21)-positive acute lymphoblastic leukemia. Leuk Res 32:39-43.
  • Bezrookove V, van Zelderen-Bhola SL, Brink A, Szuhai K, Raap AK, Barge R, Beverstook CG, Rosenberg C (2004) A novel t(6;14)(q25~q27;q32) in acute myelocytic leukemia involves the BCL11B gene. Cancer Genet Cytogenet 149: 72-76.
  • Brezinova J, Zemanova Z, Ransdorfova S, Sindelarova L, Siskova M, Neuwirtova R, Cermak J, Michalova K (2005) Prognostic significance of del(20q) in patients with hematological malignancies. Cancer Genet Cytogenet 160: 188-192
  • Brizard F, Cividin M, Villalva C, Guilhot F, Brizard A (2004) Comparison of M-FISH and conventional cytogenetic analysis in accelerated and acute phases of CML. Leuk Res 28:345-348
  • Calabrese G, Fantasia D, Franch PG, Morizio E, Stuppia L, Gatta V, Olioso P, Mingarelli R, Spadano A, Palka G (2000) Spectral karyotyping (SKY) refinement of a complex karyotype with t(20;21) in a Ph-positive CML patient submitted to peripheral blood stem cell transplantation. Bone Marrow Transplant 26: 1125-1127.
  • Calabrese G, Fantasia D, Morizio E, Toro PM, Franchi PG, Fornaro A, Spadano A, Stuppia L, Palka G (2003) Chromosome 11 rearrangements and specific MLL amplification revealed by spectral karyotyping in a patient with refractory anaemia with excess of blasts (RAEB).Br J Haematol 122:760-763
  • Chae H, Kim M, Lim J, Kim Y, Han K, Lee S (2010) B lymphoblastic leukemia with ETV6 amplification. Cancer Genet Cytogenet 203:284-287.
  • Chen BA, Xia GH, Li JY, Xiao B, Shao ZY, Chen NN, Gao C, Wu YJ (2006) Detection of complex karyotype in a myelodysplastic syndrome cell line (MUTZ-1) by metaphase fluorescence in situ hybridization. Zhongguo Shi Yan Xue Ye Xue Za Zhi 14:46-49
  • Chen S, Xue Y, Zhang X, Wu Y, Pan J, Wang Y, Ceng J (2005) A new human acute monocytic leukemia cell line SHI-1 with t(6;11)(q27;q23), p53 gene alterations and high tumorigenicity in nude mice. Haematologica 90:766-775
  • Chen LJ, Li JY, Xiao B, Zhu Y, Liu Q, Pan JL, Qiu HR, Fan L, Zhang SJ, Lu RN, Xu W, Xue YQ (2007) [Analysis of complex chromosomal aberrations in patients with myelodysplastic syndromes using multiplex fluorescence in situ hybridization combined with whole chromosome painting] Zhonghua Yi Xue Yi Chuan Xue Za Zhi 24:635-639. Chinese.
  • Cigudosa JC, Odero MD, Calasanz MJ, Sole F, Salido M, Arranz E, Martinez-Ramirez A, Urioste M, Alvarez S, Cervera JV, MacGrogan D, Sanz MA, Nimer SD, Benitez J (2003) De novo erythroleukemia chromosome features include multiple rearrangements, with special involvement of chromosomes 11 and 19. Genes Chromosomes Cancer 36: 406-412.
  • Cohen N, Trakhtenbrot L, Yukla M, Mandor Y, Gaber E, Yosef G, Amariglio N, Rechavi G, Amiel A (2002) SKY detection of chromosome rearrangements in two cases of tMDS with a complex karyotype. Cancer Genet Cytogenet 138: 128-132.
  • Collado R, Hueso J, Cabello AI, Oliver I, Egea M, Orero M, Miguel-Sosa A, Cigudosa JC, Benitez J, Barragan E, Carbonell F (2006) New translocations in a case of atypical B-cell chronic lymphocytic leukemia: involvement of ATM, MLL, and TP53 genes. Cancer Genet Cytogenet 169:176-178.
  • Corral Mdel P, Villa O, Alfaro EM, Alonso CN, Baro C, Felice MS, Rossi J, Solé F, Gallego MS (2008) Complex chromosome 8;21 translocation with associated hyperdiploidy in acute myeloid leukemia (FAB-M2). Pediatr Blood Cancer 50:651-654
  • Cox MC, Panetta P, Lo-Coco F, Del Poeta G, Venditti A, Maurillo L, Del Principe MI, Mauriello A, Anemona L, Bruno A, Mazzone C, Palombo P, Amadori S (2004) Chromosomal aberration of the 11q23 locus in acute leukemia and frequency of MLL gene translocation: results in 378 adult patients. Am J Clin Pathol 122:298-306
  • Crescenzi B, La Starza R, Nozzoli C, Ciolli S, Matteucci C, Romoli S, Rigacci L, Gorello P, Bosi A, Martelli MF, Marynen P, Mecucci C (2007) Molecular cytogenetic findings in a four-way t(1;12;5;12)(p36;p13;q33;q24) underlying the ETV6-PDGFRB fusion gene in chronic myelomonocytic leukemia. Cancer Genet Cytogenet 176:67-71.
  • Dai H, Xue Y, Pan J, Wu Y, Wang Y, Shen J, Zhang J (2007) Two novel translocations disrupt the RUNX1 gene in acute myeloid leukemia. Cancer Genet Cytogenet 177:120-124
  • Dalley CD, Neat MJ, Foot NJ, Burridge M, Byrne L, Amess JA, Rohatiner AZ, Lister A, Young BD, Lillington DM (2002) Comparative genomic hybridization and multiplex-fluorescence in situ hybridization: an appraisal in elderly patients with acute myelogenous leukemia. Hematol J 3:290-298
  • Davidsson J, Paulsson K, Johansson B (2005 Multicolor fluorescence in situ hybridization characterization of cytogenetically polyclonal hematologic malignancies. Cancer Genet Cytogenet 163:180-183.
  • de Oliveira FM, Tone LG, Simoes BP, Falcao RP, Brassesco MS, Sakamoto-Hojo ET, dos Santos GA, Marinato AF, Jacomo RH, Rego EM (2007) Acute myeloid leukemia (AML-M2) with t(5;11)(q35;q13) and normal expression of cyclin D1. Cancer Genet Cytogenet 172:154-157.
  • de Oliveira FM, Tone LG, Simões BP, Rego EM, Marinato AF, Jácomo RH, Falcão RP (2008) Translocations t(X;14)(q28;q11) and t(Y;14)(q12;q11) in T-cell prolymphocytic leukemia. Int J Lab Hematol. 2008 Feb 21; [Epub ahead of print]
  • de Oliveira FM, Falcão RP, de Figueiredo Pontes LL, Simões BP, Tone LG (2008) Insertion (15;14)(q22;q13q32) in a case of Ph+ ALL. Cancer Genet Cytogenet 185:65-67.
  • de Oliveira FM, de Figueiredo Pontes LL, Bassi SC, Dalmazzo LF, Falcão RP (2011) Co-existence of t(6;13)(p21;q14.1) and trisomy 12 in chronic lymphocytic leukemia. Med Oncol [Epub ahead of print]
  • de Jesus Marques-Salles T, Mkrtchyan H, Pereira Leite E, Soares-Ventura EM, Cartaxo-Muniz MT, Ferreira E, Liehr T, Macedo Silva ML, Santos N (2010) Complex karyotype defined by FISH and M-FISH studies in an infant with acute megakarioblastic leukemia and neurofibromatosis. Cancer Genet Cytogenet 200: 167-169.
  • Douet-Guilbert N, Basinko A, Eveillard JR, Morel F, Le Bris MJ, Guéganic N, Bovo C, Herry A, Berthou C, De Braekeleer M (2010) Three rearrangements of chromosome 5 in a patient with myelodysplastic syndrome: an atypical deletion 5q, a complex intrachromosomal rearrangement of chromosome 5, and a paracentric inversion of chromosome 5. Cancer Genet Cytogenet 203:303-308.
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  • Fan YS, Siu VM, Jung JH, Xu J (2000) Sensitivity of multiple color spectral karyotyping in detecting small interchromosomal rearrangements. Genet Test 4:9-14.
  • Faria De Figueiredo A, Liehr T, Bhatt S, Binato R, Tavares De Souza M, Rodrigues Capela De Matos R, De Jesus Marques Salles T, Jordy FC, Ribeiro RC, Abdelhay E, Luiza Macedo Silva M (2011) A complex karyotype masked a cryptic variant t(8;21)(q22;q22) in a child with acute myeloid leukemia. Leuk Lymphoma 52:1593-1596.
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  • Gribble SM, Reid AG, Roberts I, Grace C, Green AR, Nacheva EP (2003) Genomic imbalances in CML blast crisis: 8q24.12-q24.13 segment identified as a common region of over-representation. Genes Chromosomes Cancer 37: 346-358.
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Lymphoma

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Solid tumors

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Cell lines

see also SKY Karyotypes and FISH analysis of Epithelial Cancer Cell Lines at
http://www.path.cam.ac.uk/~pawefish/

see also SKY/M-FISH and CGH Database
http://www.ncbi.nlm.nih.gov/sky/skyweb.cgi

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